Velpaclear is one of the generic versions of Epclusa which is produced by Abbott. This medicine is available in the form of tablets that containing of Sofosbuvir 400 mg and Velpatasvir 100 mg. Hepatitis C virus can found in several genotypes, and Velpaclear can be used to treat hepatitis C caused by all genotypes of the virus.
Who can use Velpaclear (Generic Epclusa) ?
Velpaclear is approved for people with HCV genotypes 1, 2, 3, 4, 5 and 6. Genotype 1 is the most common type in Europe. Genotype 3 is considered hardest to treat with direct-acting antivirals. Some people with harder-to-treat disease may do better if they take Epclusa with ribavirin. In a clinical trial where Epclusa was used along with the broad-spectrum antiviral drug ribavirin, the combination was able to cure 91% of participants who needed retreatment after their previous regimen had failed. Bear in mind that in this study 24 consecutive weeks of retreatment were necessary to effect such a high rate of cure.
Velpaclear can be used by people being treated for hepatitis C for the first time (known as ‘treatment naive’) and for retreatment of people who were not cured with previous therapy (known as ‘treatment experienced’).
Velpaclear can be used by people with all stages of liver disease, including compensated cirrhosis, decompensated cirrhosis (laboratory abnormalities or symptoms of poor liver function) and people who are awaiting or have received a liver transplant.
How effective is Velpaclear ?
Velpaclear works better for some people than for others. Several factors predict how well someone will respond, including HCV genotype, extent of liver damage and previous treatment history.
People with advanced liver disease do not respond as well as those with mild or moderate liver fibrosis. This may be overcome by adding ribavirin, which helps prevent relapse. People who are new to treatment have a better chance of being cured than those who did not respond to prior treatment.
Velpaclear's effectiveness in ‘real world’ use may be somewhat lower than cure rates seen in clinical trials, in part because patients may be sicker or have other conditions that make treatment more complicated.
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